{"id":783585,"date":"2026-05-09T05:53:47","date_gmt":"2026-05-09T05:53:47","guid":{"rendered":""},"modified":"2026-05-09T19:23:45","modified_gmt":"2026-05-09T19:23:45","slug":"cytochrome-c-mitochondrial-markerrcycs-1010-0-2mg-ml-bt-a-bnub3641","status":"publish","type":"product","link":"https:\/\/immunomart.com\/product\/cytochrome-c-mitochondrial-markerrcycs-1010-0-2mg-ml-bt-a-bnub3641\/","title":{"rendered":"Cytochrome C (Mitochondrial Marker)(rCYCS\/1010), 0.2mg\/mL"},"content":{"rendered":"<p>Recognizes an epitope within amino acids 93-104 of pigeon Cytochrome C, a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. This MAb recognizes total cytochrome C which includes both apocytochrome (i. e. cytochrome in the cytosol without heme attached) and holocytochrome (i. e cytochrome in the mitochondria with heme attached). Primary antibodies are available purified, or with a selection of fluorescent CF\u00ae Dyes and other labels. CF\u00ae Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF\u00ae405S and CF\u00ae405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.<\/p>\n<div style=\"margin:18px 0 4px;padding:11px 14px;background:#fdf4f4;border:1px solid #e6bdbd;border-left:3px solid #c41e3a;border-radius:4px;font-size:13px;line-height:1.55;color:#3a3a3a;\"><strong style=\"color:#8a1524;\">For Research Use Only (RUO).<\/strong> This product is sold strictly for laboratory research use only. <strong>Not for human or veterinary consumption, therapeutic, or diagnostic use.<\/strong> Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Recognizes an epitope within amino acids 93-104 of pigeon Cytochrome C, a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for [&hellip;]<\/p>\n","protected":false},"featured_media":721298,"template":"","meta":{"_acf_changed":false,"ep_exclude_from_search":false},"product_brand":[1638],"product_cat":[2344,2339],"product_tag":[],"class_list":{"0":"post-783585","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_brand-biotium","7":"product_cat-apoptosis","8":"product_cat-biotium-antibodies","9":"pa_antibody_type-primary","10":"pa_application-ffpe","11":"pa_application-flow","12":"pa_application-ihc","13":"pa_application-intracellular","14":"pa_application-wb","15":"pa_clonality-recombinant-monoclonal","16":"pa_conjugate-unconjugated","17":"pa_host-mouse","18":"pa_isotype-igg1-kappa","19":"pa_localization-mitochondria","20":"pa_product_class-primary-antibody","21":"pa_purification-with-bsa","22":"pa_size-100-l","23":"pa_size-500-l","24":"pa_species_reactivity-dog","25":"pa_species_reactivity-drosophila","26":"pa_species_reactivity-frog","27":"pa_species_reactivity-horse","28":"pa_species_reactivity-human","29":"pa_species_reactivity-mouse","30":"pa_species_reactivity-pigeon","31":"pa_species_reactivity-rat","33":"first","34":"instock","35":"taxable","36":"shipping-taxable","37":"purchasable","38":"product-type-variable"},"acf":[],"_links":{"self":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product\/783585","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/media\/721298"}],"wp:attachment":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/media?parent=783585"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_brand?post=783585"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_cat?post=783585"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_tag?post=783585"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}