{"id":775588,"date":"2026-05-09T03:48:42","date_gmt":"2026-05-09T03:48:42","guid":{"rendered":"https:\/\/immunomart.com\/?post_type=product&p=775588"},"modified":"2026-05-09T19:23:45","modified_gmt":"2026-05-09T19:23:45","slug":"thymidine-phosphorylase-pd-ecgf-angiogenesis-marker-tymp-2890r-cf740-conjugate-0-1mg-ml-bt-a-bnc742890","status":"publish","type":"product","link":"https:\/\/immunomart.com\/product\/thymidine-phosphorylase-pd-ecgf-angiogenesis-marker-tymp-2890r-cf740-conjugate-0-1mg-ml-bt-a-bnc742890\/","title":{"rendered":"Thymidine Phosphorylase \/ PD-ECGF (Angiogenesis Marker) (TYMP\/2890R), CF740 conjugate, 0.1mg\/mL"},"content":{"rendered":"<p>This antibody recognizes a protein (amino acid 482) of 55 kDa (in vivo 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP\/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5\u20ac\u2122-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP\/PD-ECGF are associated with increased chemosensitivity to such antimetabolites<\/p>\n<p>Primary antibodies are available purified, or with a selection of fluorescent CF\u00ae Dyes and other labels. CF\u00ae Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF\u00ae405S and CF\u00ae405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.<\/p>\n<div style=\"margin:18px 0 4px;padding:11px 14px;background:#fdf4f4;border:1px solid #e6bdbd;border-left:3px solid #c41e3a;border-radius:4px;font-size:13px;line-height:1.55;color:#3a3a3a;\"><strong style=\"color:#8a1524;\">For Research Use Only (RUO).<\/strong> This product is sold strictly for laboratory research use only. <strong>Not for human or veterinary consumption, therapeutic, or diagnostic use.<\/strong> Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>This antibody recognizes a protein (amino acid 482) of 55 kDa (in vivo 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both [&hellip;]<\/p>\n","protected":false},"featured_media":720418,"template":"","meta":{"_acf_changed":false,"ep_exclude_from_search":false},"product_brand":[1638],"product_cat":[2347,2339,2357],"product_tag":[],"class_list":{"0":"post-775588","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_brand-biotium","7":"product_cat-angiogenesis","8":"product_cat-biotium-antibodies","9":"product_cat-metabolism","10":"pa_antibody_type-primary","11":"pa_application-ffpe","12":"pa_application-ihc","13":"pa_clonality-recombinant-monoclonal","14":"pa_conjugate-cf740","15":"pa_host-rabbit","16":"pa_isotype-igg","17":"pa_localization-nucleus-cytoplasm-2","18":"pa_product_class-primary-antibody","19":"pa_size-100-l","20":"pa_size-500-l","21":"pa_species_reactivity-human","22":"pa_species_reactivity-mouse","23":"pa_species_reactivity-rat","25":"first","26":"instock","27":"taxable","28":"shipping-taxable","29":"purchasable","30":"product-type-variable"},"acf":[],"_links":{"self":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product\/775588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/media\/720418"}],"wp:attachment":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/media?parent=775588"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_brand?post=775588"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_cat?post=775588"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_tag?post=775588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}