{"id":767724,"date":"2026-05-09T01:56:03","date_gmt":"2026-05-09T01:56:03","guid":{"rendered":"https:\/\/immunomart.com\/?post_type=product&p=767724"},"modified":"2026-05-09T19:23:45","modified_gmt":"2026-05-09T19:23:45","slug":"tim3-havcr2-cd366-effector-t-cell-markerhavcr2-192-cf647-conjugate-0-1mg-ml-bt-a-bnc472399","status":"publish","type":"product","link":"https:\/\/immunomart.com\/product\/tim3-havcr2-cd366-effector-t-cell-markerhavcr2-192-cf647-conjugate-0-1mg-ml-bt-a-bnc472399\/","title":{"rendered":"TIM3 \/ HAVCR2 \/ CD366 (Effector T-Cell Marker)(HAVCR2\/192), CF647 conjugate, 0.1mg\/mL"},"content":{"rendered":"<p>TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser\/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cells (CD4 Th1 and CD8 Tc1) but not on helper T cells (CD4 Th2 and CD8 Tc2). In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation. Primary antibodies are available purified, or with a selection of fluorescent CF\u00ae Dyes and other labels. CF\u00ae Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF\u00ae405S and CF\u00ae405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.<\/p>\n<div style=\"margin:18px 0 4px;padding:11px 14px;background:#fdf4f4;border:1px solid #e6bdbd;border-left:3px solid #c41e3a;border-radius:4px;font-size:13px;line-height:1.55;color:#3a3a3a;\"><strong style=\"color:#8a1524;\">For Research Use Only (RUO).<\/strong> This product is sold strictly for laboratory research use only. <strong>Not for human or veterinary consumption, therapeutic, or diagnostic use.<\/strong> Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser\/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cells (CD4 Th1 and CD8 Tc1) but not on helper T cells (CD4 Th2 and CD8 Tc2). In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several [&hellip;]<\/p>\n","protected":false},"featured_media":720992,"template":"","meta":{"_acf_changed":false,"ep_exclude_from_search":false},"product_brand":[1638],"product_cat":[2339],"product_tag":[],"class_list":{"0":"post-767724","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_brand-biotium","7":"product_cat-biotium-antibodies","8":"pa_antibody_type-primary","9":"pa_application-ffpe","10":"pa_application-ihc","11":"pa_clonality-monoclonal","12":"pa_conjugate-cf647","13":"pa_host-mouse","14":"pa_isotype-igg2a-kappa","15":"pa_localization-plasma-membrane","16":"pa_product_class-primary-antibody","17":"pa_size-100-l","18":"pa_size-500-l","19":"pa_species_reactivity-human","21":"first","22":"instock","23":"taxable","24":"shipping-taxable","25":"purchasable","26":"product-type-variable"},"acf":[],"_links":{"self":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product\/767724","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/media\/720992"}],"wp:attachment":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/media?parent=767724"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_brand?post=767724"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_cat?post=767724"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_tag?post=767724"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}