{"id":765240,"date":"2026-05-09T01:23:52","date_gmt":"2026-05-09T01:23:52","guid":{"rendered":"https:\/\/immunomart.com\/?post_type=product&p=765240"},"modified":"2026-05-09T19:23:45","modified_gmt":"2026-05-09T19:23:45","slug":"calcineurin-b-homologous-protein-2-hcc-antigen-520cptc-chp2-1-biotin-conjugate-0-1mg-ml-bt-a-bncb2266","status":"publish","type":"product","link":"https:\/\/immunomart.com\/product\/calcineurin-b-homologous-protein-2-hcc-antigen-520cptc-chp2-1-biotin-conjugate-0-1mg-ml-bt-a-bncb2266\/","title":{"rendered":"Calcineurin B homologous protein 2 \/ HCC Antigen 520(CPTC-CHP2-1), Biotin conjugate, 0.1mg\/mL"},"content":{"rendered":"<p>Calcineurin B homologous protein 2, also known as hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains 4 EF-hand domains and plays a potential role in transmembrane Na\/H exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin\/NFAT signaling pathway. Primary antibodies are available purified, or with a selection of fluorescent CF\u00ae Dyes and other labels. CF\u00ae Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF\u00ae405S and CF\u00ae405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.<\/p>\n<div style=\"margin:18px 0 4px;padding:11px 14px;background:#fdf4f4;border:1px solid #e6bdbd;border-left:3px solid #c41e3a;border-radius:4px;font-size:13px;line-height:1.55;color:#3a3a3a;\"><strong style=\"color:#8a1524;\">For Research Use Only (RUO).<\/strong> This product is sold strictly for laboratory research use only. <strong>Not for human or veterinary consumption, therapeutic, or diagnostic use.<\/strong> Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Calcineurin B homologous protein 2, also known as hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains 4 EF-hand domains and plays a potential role in transmembrane Na\/H exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected [&hellip;]<\/p>\n","protected":false},"featured_media":721013,"template":"","meta":{"_acf_changed":false,"ep_exclude_from_search":false},"product_brand":[1638],"product_cat":[2339,2379],"product_tag":[],"class_list":{"0":"post-765240","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_brand-biotium","7":"product_cat-biotium-antibodies","8":"product_cat-ion-channels","9":"pa_antibody_type-primary","10":"pa_application-if","11":"pa_application-wb","12":"pa_clonality-monoclonal","13":"pa_conjugate-biotin","14":"pa_host-mouse","15":"pa_isotype-igg2c-kappa","16":"pa_localization-nucleus-cytoplasm-2","17":"pa_product_class-primary-antibody","18":"pa_size-100-l","19":"pa_size-500-l","20":"pa_species_reactivity-human","22":"first","23":"instock","24":"taxable","25":"shipping-taxable","26":"purchasable","27":"product-type-variable"},"acf":[],"_links":{"self":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product\/765240","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/media\/721013"}],"wp:attachment":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/media?parent=765240"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_brand?post=765240"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_cat?post=765240"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_tag?post=765240"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}