{"id":762811,"date":"2026-05-09T00:53:06","date_gmt":"2026-05-09T00:53:06","guid":{"rendered":"https:\/\/immunomart.com\/?post_type=product&p=762811"},"modified":"2026-05-09T19:23:45","modified_gmt":"2026-05-09T19:23:45","slug":"pu-1-spi-1-b-cell-marker-pu1-2146-cf640r-conjugate-0-1mg-ml-bt-a-bnc402146","status":"publish","type":"product","link":"https:\/\/immunomart.com\/product\/pu-1-spi-1-b-cell-marker-pu1-2146-cf640r-conjugate-0-1mg-ml-bt-a-bnc402146\/","title":{"rendered":"PU.1 (SPI-1) (B-Cell Marker) (PU1\/2146), CF640R conjugate, 0.1mg\/mL"},"content":{"rendered":"<p>PU.1 is a member of the ETS family of transcription factors and is important for normal B-cell development. It is expressed in the myeloid lineage and in immature as well as mature B-lymphocytes, with the exception of plasma cells. PU.1 is expressed in germinal center B-cells and mantle B-cells. Various lymphomas are also positive for this marker. It is essential during early B-cell differentiation. The absence of PU.1 results in total block of B-cell development at the pre-pro stage. PU.1 plays a key role in normal myeloid differentiation, and regulates the expression of immunoglobulin and other genes that are important for B-cell development.<\/p>\n<p>Primary antibodies are available purified, or with a selection of fluorescent CF\u00ae Dyes and other labels. CF\u00ae Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF\u00ae405S and CF\u00ae405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.<\/p>\n<div style=\"margin:18px 0 4px;padding:11px 14px;background:#fdf4f4;border:1px solid #e6bdbd;border-left:3px solid #c41e3a;border-radius:4px;font-size:13px;line-height:1.55;color:#3a3a3a;\"><strong style=\"color:#8a1524;\">For Research Use Only (RUO).<\/strong> This product is sold strictly for laboratory research use only. <strong>Not for human or veterinary consumption, therapeutic, or diagnostic use.<\/strong> Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>PU.1 is a member of the ETS family of transcription factors and is important for normal B-cell development. It is expressed in the myeloid lineage and in immature as well as mature B-lymphocytes, with the exception of plasma cells. PU.1 is expressed in germinal center B-cells and mantle B-cells. Various lymphomas are also positive for [&hellip;]<\/p>\n","protected":false},"featured_media":719993,"template":"","meta":{"_acf_changed":false,"ep_exclude_from_search":false},"product_brand":[1638],"product_cat":[2339,2342,2368],"product_tag":[],"class_list":{"0":"post-762811","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_brand-biotium","7":"product_cat-biotium-antibodies","8":"product_cat-immunology","9":"product_cat-transcription-factors","10":"pa_antibody_type-primary","11":"pa_application-ffpe","12":"pa_application-flow","13":"pa_application-if","14":"pa_application-ihc","15":"pa_application-intracellular","16":"pa_application-wb","17":"pa_clonality-monoclonal","18":"pa_conjugate-cf640r","19":"pa_host-mouse","20":"pa_isotype-igg2b-kappa","21":"pa_localization-nucleus","22":"pa_product_class-primary-antibody","23":"pa_size-100-l","24":"pa_size-500-l","25":"pa_species_reactivity-human","27":"first","28":"instock","29":"taxable","30":"shipping-taxable","31":"purchasable","32":"product-type-variable"},"acf":[],"_links":{"self":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product\/762811","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/media\/719993"}],"wp:attachment":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/media?parent=762811"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_brand?post=762811"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_cat?post=762811"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_tag?post=762811"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}