{"id":762450,"date":"2026-05-09T00:48:54","date_gmt":"2026-05-09T00:48:54","guid":{"rendered":"https:\/\/immunomart.com\/?post_type=product&p=762450"},"modified":"2026-05-09T19:23:45","modified_gmt":"2026-05-09T19:23:45","slug":"ubiquitin-autophagy-marker-ubb-2122-cf647-conjugate-0-1mg-ml-bt-a-bnc472122","status":"publish","type":"product","link":"https:\/\/immunomart.com\/product\/ubiquitin-autophagy-marker-ubb-2122-cf647-conjugate-0-1mg-ml-bt-a-bnc472122\/","title":{"rendered":"Ubiquitin (Autophagy Marker) (UBB\/2122), CF647 conjugate, 0.1mg\/mL"},"content":{"rendered":"<p>Ubiquitin is a highly conserved and plays an essential role in the ubiquitin-proteasome pathway. In ubiquitination process, it is first activated by forming a thiol-ester complex with the activation component E1, which is then transferred to ubiquitin-carrier protein E2, followed by to ubiquitin ligase E3 for final delivery to epsilon-NH2 of the target protein lysine residue. IkB, p53, cdc25A, Bcl-2 etc. are shown as targets of ubiquitin-proteasome process as part of regulation of cell cycle progression, differentiation, cell stress response, and apoptosis. Moreover, ubiquitin have been reported to bind covalently with pathological inclusions which are resistant to degradation e.g. neurofibrillary tangles\/paired helical filaments in Alzheimer&#8217;s disease, Lewy bodies seen in Parkinson&#8217;s disease, and Pick bodies found in Pick&#8217;s disease etc.Primary antibodies are available purified, or with a selection of fluorescent CF\u00ae Dyes and other labels. CF\u00ae Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF\u00ae405S and CF\u00ae405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.<\/p>\n<div style=\"margin:18px 0 4px;padding:11px 14px;background:#fdf4f4;border:1px solid #e6bdbd;border-left:3px solid #c41e3a;border-radius:4px;font-size:13px;line-height:1.55;color:#3a3a3a;\"><strong style=\"color:#8a1524;\">For Research Use Only (RUO).<\/strong> This product is sold strictly for laboratory research use only. <strong>Not for human or veterinary consumption, therapeutic, or diagnostic use.<\/strong> Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Ubiquitin is a highly conserved and plays an essential role in the ubiquitin-proteasome pathway. In ubiquitination process, it is first activated by forming a thiol-ester complex with the activation component E1, which is then transferred to ubiquitin-carrier protein E2, followed by to ubiquitin ligase E3 for final delivery to epsilon-NH2 of the target protein lysine [&hellip;]<\/p>\n","protected":false},"featured_media":719958,"template":"","meta":{"_acf_changed":false,"ep_exclude_from_search":false},"product_brand":[1638],"product_cat":[2339,2382],"product_tag":[],"class_list":{"0":"post-762450","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_brand-biotium","7":"product_cat-biotium-antibodies","8":"product_cat-ubiquitination","9":"pa_antibody_type-primary","10":"pa_application-ffpe","11":"pa_application-ihc","12":"pa_application-wb","13":"pa_clonality-monoclonal","14":"pa_conjugate-cf647","15":"pa_host-mouse","16":"pa_isotype-igg1-kappa","17":"pa_localization-cytoplasmic","18":"pa_localization-nucleus","19":"pa_localization-plasma-membrane","20":"pa_product_class-primary-antibody","21":"pa_size-100-l","22":"pa_size-500-l","23":"pa_species_reactivity-human","25":"first","26":"instock","27":"taxable","28":"shipping-taxable","29":"purchasable","30":"product-type-variable"},"acf":[],"_links":{"self":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product\/762450","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/media\/719958"}],"wp:attachment":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/media?parent=762450"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_brand?post=762450"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_cat?post=762450"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_tag?post=762450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}