{"id":746305,"date":"2026-05-08T06:51:56","date_gmt":"2026-05-08T06:51:56","guid":{"rendered":"https:\/\/immunomart.com\/?post_type=product&p=746305"},"modified":"2026-05-09T19:23:45","modified_gmt":"2026-05-09T19:23:45","slug":"maml2-mastermind-like-transcriptional-coactivator-2-maml2-1302-cf405s-conjugate-0-1mg-ml-bt-a-bnc041302","status":"publish","type":"product","link":"https:\/\/immunomart.com\/product\/maml2-mastermind-like-transcriptional-coactivator-2-maml2-1302-cf405s-conjugate-0-1mg-ml-bt-a-bnc041302\/","title":{"rendered":"MAML2 (Mastermind Like Transcriptional Coactivator 2) (MAML2\/1302), CF405S conjugate, 0.1mg\/mL"},"content":{"rendered":"<p>MAML2 (mastermind-like protein 2), also known as MAM2, MAM3 or MLLMAML2, is a nuclear speckle protein that acts as a transcriptional co-activator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML2 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML2 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-J, a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML2 is essential for proper Notch binding, the C-terminal domain of MAML2 is essential for transcriptional activation. A chromosomal aberration involving the gene encoding MAML2 is implicated in mucoepidermoid carcinomas, clear cell hidradenomas and benign Warthin tumors.Primary antibodies are available purified, or with a selection of fluorescent CF\u00ae Dyes and other labels. CF\u00ae Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF\u00ae405S and CF\u00ae405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.<\/p>\n<div style=\"margin:18px 0 4px;padding:11px 14px;background:#fdf4f4;border:1px solid #e6bdbd;border-left:3px solid #c41e3a;border-radius:4px;font-size:13px;line-height:1.55;color:#3a3a3a;\"><strong style=\"color:#8a1524;\">For Research Use Only (RUO).<\/strong> This product is sold strictly for laboratory research use only. <strong>Not for human or veterinary consumption, therapeutic, or diagnostic use.<\/strong> Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>MAML2 (mastermind-like protein 2), also known as MAM2, MAM3 or MLLMAML2, is a nuclear speckle protein that acts as a transcriptional co-activator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML2 is a member of the mastermind-like family of proteins [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"ep_exclude_from_search":false},"product_brand":[1638],"product_cat":[2339,2341,2343],"product_tag":[],"class_list":{"0":"post-746305","1":"product","2":"type-product","3":"status-publish","5":"product_brand-biotium","6":"product_cat-biotium-antibodies","7":"product_cat-developmental-biology","8":"product_cat-signal-transduction","9":"pa_antibody_type-primary","10":"pa_application-ffpe","11":"pa_application-ihc","12":"pa_clonality-monoclonal","13":"pa_conjugate-cf405s","14":"pa_host-mouse","15":"pa_isotype-igg2a","16":"pa_localization-cytoplasmic","17":"pa_localization-nucleus","18":"pa_product_class-primary-antibody","19":"pa_size-100-l","20":"pa_size-500-l","21":"pa_species_reactivity-human","23":"first","24":"instock","25":"taxable","26":"shipping-taxable","27":"purchasable","28":"product-type-variable"},"acf":[],"_links":{"self":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product\/746305","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/types\/product"}],"wp:attachment":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/media?parent=746305"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_brand?post=746305"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_cat?post=746305"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_tag?post=746305"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}