{"id":717007,"date":"2026-05-05T03:07:16","date_gmt":"2026-05-05T03:07:16","guid":{"rendered":"https:\/\/immunomart.com\/?post_type=product&p=717007"},"modified":"2026-05-05T05:44:50","modified_gmt":"2026-05-05T05:44:50","slug":"nucview-488-caspase-3-substrate-1mm-in-dmso","status":"publish","type":"product","link":"https:\/\/immunomart.com\/product\/nucview-488-caspase-3-substrate-1mm-in-dmso\/","title":{"rendered":"NucView\u00ae 488 Caspase-3 Substrate, 1mM in DMSO"},"content":{"rendered":"<p>NucView\u00ae 488 Caspase-3 Substrate is a novel cell membrane-permeable fluorogenic caspase substrate designed for detecting caspase-3\/7 activity within live cells in real time. Unlike conventional caspase assays, NucView\u00ae 488 Caspase-3 Substrate detects caspase-3\/7 activity within individual intact cells without inhibiting caspase activity. The substrate consists of a fluorogenic DNA dye and a DEVD substrate moiety specific for caspase-3\/7. The substrate, which is both non-fluorescent and nonfunctional as a DNA dye, rapidly crosses cell membranes to enter the cytoplasm, where it is cleaved by caspase-3 to form a high-affinity DNA dye that stains the nucleus bright green. Thus, the NucView\u00ae 488 Caspase-3 Substrate is bi-functional, allowing detection of intracellular caspase-3\/7 activity and visualization of changes in nuclear morphology during apoptosis. The fluorescent staining produced in response to caspase-3\/7 activity is compatible with subsequent fixation and permeabilization for immunostaining.\u00a0\u00a0NucView\u00ae488 Caspase-3 Substrate, also is available as a 1 mM solution in PBS (phosphate-buffered saline) for use in cells that are sensitive to DMSO toxicity. \u00a0\u00a0NucView\u00ae enzyme substrate technology is covered by U.S. patents.<\/p>\n<h3>Handling<\/h3>\n<p>Protect from light;<\/p>\n<div style=\"margin:18px 0 4px;padding:11px 14px;background:#fdf4f4;border:1px solid #e6bdbd;border-left:3px solid #c41e3a;border-radius:4px;font-size:13px;line-height:1.55;color:#3a3a3a\"><strong style=\"color:#8a1524\">For Research Use Only (RUO).<\/strong> This product is sold strictly for laboratory research use only. <strong>Not for human or veterinary consumption, therapeutic, or diagnostic use.<\/strong> Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>NucView\u00ae 488 Caspase-3 Substrate is a novel cell membrane-permeable fluorogenic caspase substrate designed for detecting caspase-3\/7 activity within live cells in real time. Unlike conventional caspase assays, NucView\u00ae 488 Caspase-3 Substrate detects caspase-3\/7 activity within individual intact cells without inhibiting caspase activity. The substrate consists of a fluorogenic DNA dye and a DEVD substrate moiety [&hellip;]<\/p>\n","protected":false},"featured_media":714610,"template":"","meta":{"_acf_changed":false,"ep_exclude_from_search":false},"product_brand":[1638],"product_cat":[1647,1685,1660,1683],"product_tag":[2080],"class_list":{"0":"post-717007","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_brand-biotium","7":"product_cat-biotium-apoptosis-assays","8":"product_cat-biotium-flow-cytometry","9":"product_cat-biotium-nucview-caspase-3-substrates","10":"product_cat-biotium-protease-substrates","11":"product_tag-top-biotium","12":"pa_size-10-l","13":"pa_size-100-l","15":"first","16":"instock","17":"taxable","18":"shipping-taxable","19":"purchasable","20":"product-type-variable"},"acf":[],"_links":{"self":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product\/717007","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/media\/714610"}],"wp:attachment":[{"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/media?parent=717007"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_brand?post=717007"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_cat?post=717007"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/immunomart.com\/wp-json\/wp\/v2\/product_tag?post=717007"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}