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NuMA(A73-B/D12), 0.2mg/mL

SKU BT-A-BNUB0939 Categories Biotium Antibodies, Cancer, Cell cycle Brand: Biotium

Price range: 233 USD through 502 USD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.Intended for use by research organizations and laboratories only; not for patients or for personal use.

Size

100 μL 500 μL

Clear

Products Details

Product Description

–

Recognizes a phosphorylated protein of 228 kDa, identified as nuclear mitotic apparatus protein (NuMA). Its epitope is resistant to phosphatases. NuMA is intra-nuclear protein and present in nucleus during interphase. At the onset of mitosis, it redistributes from the nucleus to two centrosomal structures that later will become part of the mitotic spindle pole. After anaphase, the protein redistributes from the spindle polar region into reforming nucleus. NuMA is an essential protein during mitosis for the terminal phases of chromosome separation and/or nuclear reassembly. Recently a study shows that NuMA is cleaved to a 180 to 200 kDa during apoptosis. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 has been detected in patients with acute promyelocytic leukemia.This antibody is available purified with BSA/azide at 200 ug/mL, or BSA/azide-free at 1 mg/mL.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, [cosmetic chemistry research literature], or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Storage Temperature

– 2-8 °C (Refrigerator)

Shipping

– Room temperature

Applications

– IHC, FFPE (verified)

Antibody Type

– Primary

Antibody Host

– Mouse

Antibody Isotype

– IgM, kappa

Molecular Weight

Clinical Information

– Exponentially growing any cultured human cells. Tonsil or lymph node.

Research Area

– Cancer, Cell cycle

Target

– NuMA

Product type

– Primary Antibody

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.